Long-chain noncoding RNA-GAS 5 / hsa-miR-1385 p attenuates 1 high-glucose-induced cardiomyocyte damage by targeting CYP 11 B 2 2 3 Running title : GAS 5 attenuates cardiomyocyte damage 4 5

19 Objective: Diabetic cardiomyopathy (DCM) is one of the complications experienced 20 by patients with diabetes. In recent years, long noncoding RNAs (lncRNAs) have 21 been investigated because of their role in the progression of various diseases, 22 including DCM. The purpose of this study was to explore the role of lncRNA GAS5 23 D ow naded rom http://pndpress.com /bioscirep/adf/doi/10.1042/BSR 20202232/9/bsr-2020-2232.pdf by gest on 02 Sptem er 2021 Biocience R eorts. This is an Acepted M ancript. ou re encuraged to se he Vrsion of R eord tat, w en puished, w ill relace his vesion. he m st up-tote-version is avilable at https://dg/10.1042/BSR 2002232