A novel whole-blood stimulation assay to detect and quantify memory T-cells in COVID-19 patients

William Mouton,Christelle Compagnon,Kahina Saker,Soizic Daniel,Xavier Lacoux,Bruno Pozzetto,Guy Oriol,Sophia Djebali,Franck Berthier,Jacqueline Marvel,Thierry Walzer,Karen Brengel-Pesce,Sophie Trouiller-Assant

medRxiv（2021）

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摘要

SARS-CoV-2 specific T-cells responses are essential for virus clearance. We present a novel and simple whole-blood assay allowing the detection of interferon-gamma-producing antiviral T-cells following peptide stimulation. We show that unlike neutralizing antibodies, antiviral memory T-cells persist at least 6 months in convalescent Covid-19 individuals.

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关键词

stimulation,whole-blood,t-cells

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