Focus: Precision medicine in nephrology Diagnoses of uncertain significance: kidney genetics in the 21 century

1. Department of Renal Medicine, University College London, London, UK 2. KidGen Collaborative, Australian Genomics Health Alliance, Australia 3. Department of Renal Medicine, Royal Brisbane and Women’s Hospital, Brisbane, Australia 4. Institute for Molecular Bioscience and Faculty of Medicine, The University of Queensland, Brisbane, Australia 5. Genetic Health Queensland, Royal Brisbane and Women’s Hospital, Brisbane, Australia 6. Department of Pathology and Laboratory Medicine, University of North Carolina, , Chapel Hill, NC, USA 7. Center for Genomic Medicine, Massachusetts General Hospital, Cambridge Street, Boston, USA 8. Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, USA 9. Harvard University School of Medicine, Boston, USA 10. Division of Nephrology, Boston Children’s Hospital 11. Renal Unit, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK