Incidence and mortality rate for gestational trophoblastic disease. (Preprint)

BACKGROUND Gestational trophoblastic disease is a pregnancy anomaly that represents a series of invasive diseases that can metastasize or lead to death. Risk factors are genetic, racial, nutritional, and social. OBJECTIVE Analyze the number of cases of gestational trophoblastic disease, the incidence and risk factor among all patients hospitalized in Brazil from 2012 to 2017. METHODS Data collected from all hospitalizations across Brazil for hospitalized by gestational trophoblastic disease from 2012 to 2017. The incidences were calculated based on data from live births and mortality with data obtained from the Brazilian public health system. Risk factor were statistically analyzed based in race, region and age of the patients. RESULTS There were 20,534 cases of gestational trophoblastic disease with an incidence of 1.17 per 1000 live births in this period. The highest incidence was among “Asians” race (3.73 per 1000 live births; P<.001). The Brazilian regions had similar incidences, except for the Northern region, which had a lower incidence of 0.83 per 1000 live births (P=.03). The extremes of age (younger than 14 years and over 40 years) had a higher incidence compared to other women (P<.001). There were 35 deaths, and the mortality rate was 0.17% (35/20,534). The risk factors for death were living in the North region (P< .001) and “black” race (P<.001) or brown patients of color (P=.01). CONCLUSIONS The incidence found was similiar to North America and Europe. A higher incidence among "Asian" race and confirmation of higher incidence in the young and older women.