The clinical relevance of anti-fibrillarin (anti U3-RNP) autoantibodies in systemic sclerosis Short title: Anti-fibrillarin in systemic sclerosis

1 Immunology Department, AP-HP Saint-Antoine Hospital, Paris, France 2 Immunology Department, Lyon-Sud Hospital, Hospices Civils de Lyon; Claude Bernard 3 Internal Medicine Department, AP-HP Saint-Antoine Hospital, Paris, France 4 Respiratory Diseases Department, Louis Pradel Hospital, Bron, France 5 Internal Medicine Department, Lyon-Sud Hospital, Pierre-Bénite, France 6 Dermatology Department, Edouard Herriot Hospital, Lyon, France 7 Internal Medicine Department, Edouard Herriot Hospital, Lyon, France 8 Immunology Department, AP-HP Bicêtre Hospital, Kremlin Bicêtre, France 9 University Lyon I; University of Lyon; Pierre-Bénite; France 10 University Pierre et Marie Curie, UFR 967, Faculte de medecine, Paris6, France