Validation of the estimated glomerular filtration rate equation for Japanese children younger than 2 years

Background We have developed a simple and easy method of estimating the glomerular filtration rate (eGFR) of serum creatinine in Japanese children (eGFR Uemura ). The eGFR equation is for children aged 2–18 years. Therefore Uemura et al. developed an equation for children younger than 2 years (eGFR under 2 ). The aim of the present study was to validate this new equation. Methods We collected the data of 13 patients from previous studies and compared the results of eGFR under 2 , eGFR Uemura , and updated eGFR developed by Schwartz (eGFR Schwartz ) with measured GFR using mean error (ME), root mean square error (RMSE), P 30 and Bland–Altman analysis. Results The ME of eGFR under 2 , eGFR Uemura and eGFR Schwartz were 2.3 ± 15.9, 7.7 ± 14.5, and 16.0 ± 18.2 ml/min/1.73m 2 , respectively. The RMSEs were 15.5, 15.9, and 49.6, respectively. The P 30 values were 76.9%, 76.9%, and 53.8%, respectively. The graph of Bland–Altman bias analysis showed fan-shape. The eGFR under 2 equation was the most accurate in the three equations. Conclusion The eGFR under 2 equation was useful for Japanese children younger than 2 years.