Inactivated whole hepatitis C virus vaccine employing a licensed adjuvant elicits cross-genotype neutralizing antibodies in mice

Anne Finne Pihl,Shan Feng,Anna Offersgaard,Garazi Peña Alzua,Elias Honerød Augestad,Christian Kjaerulff Mathiesen,Tanja Bertelsen Jensen,Henrik Krarup,Mansun Law,Jannick Prentoe,Jan Pravsgaard Christensen,Jens Bukh,Judith Margarete Gottwein

Journal of Hepatology（2022）

引用 10|浏览18

暂无评分

摘要

•Efficient production of inactivated whole virus antigen for HCV vaccine candidates.•Whole inactivated HCV vaccines induce broadly neutralizing antibodies in mice.•Among adjuvants, AddaVax, analogue of licensed MF-59, shows the highest immunogenicity.•Modifications of HCV envelope proteins increase neutralization epitope exposure.•HCV with modified and original envelope proteins has similar immunogenicity.

查看译文

关键词

hepatitis C virus,hepatitis,neutralizing antibodies,HCV vaccine,whole viral particle vaccine,HCV inactivation,HCV downstream processing,adjuvant,envelope glycoprotein,hypervariable region,glycosylation

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要