Interferon Control of Human Coronavirus Infection and Viral Evasion: Mechanistic Insights and Implications for Antiviral Drug and Vaccine Development

•HCoVs induce innate immune response via activation of multiple intracellular pattern recognition receptors.•HCoVs subvert the induction of innate immune response and signal transduction of IFNs via multiple mechanisms.•Innate immune response plays critical roles in HCoV pathogenesis.•Multiple IFN-induced proteins inhibit distinct steps of HCoV replication.