A previously unappreciated polymorphism in the beta chain of I-As expressed in autoimmunity-prone SJL mice: Combined impact on antibody, CD4 T cell recognition and MHC class II dimer structural stability

Katherine A Richards, Courtney Lavery,Grant L J Keller,Jim Miller,Brian M Baker,Andrea J Sant

Molecular Immunology（2022）

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摘要

•A rare and unreported mutation was discovered in I-As expressed autoimmunity prone SJL mice.•A single amino acid polymorphism alters MHC class II structural features.•CD4 T cell reactivity with I-As suggests TcR docking towards peptides’ amino terminus.•Autoimmune T cells may share common features of T cell receptor recognition.

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关键词

CD4 T cells,MHC class Il structure,Polymorphism,Autoimmunity

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