SEGEM: a Fast and Accurate Automated Protein Backbone Structure Modeling Method for Cryo-EM

Cryo-electron microscopy (cryo-EM) technique has been widely used in protein structure determination, whereas it remains a challenge to automatically build accurate protein backbone structure from cryo-EM density map. A typical pipeline to automatically build a structure model from cryo-EM map is to first predict $\mathrm{C}\alpha$ sites and then assign them to protein sequence, which is a typical...