Protective effects of Huang-Lian-Jie-Du Decoction on diabetic nephropathy through regulating AGEs/RAGE/Akt/Nrf2 pathway and metabolic profiling in db/db mice

Dan Tang,Wen-Jiao He,Zhi-Tong Zhang,Jing-Jing Shi,Xue Wang,Wen-Ting Gu,Zhi-Quan Chen,You-Hua Xu,Yun-Bo Chen,Shu-Mei Wang

Phytomedicine（2022）

引用 7|浏览11

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摘要

•Network pharmacology indicated AGEs/RAGE pathway for HLJDD against diabetic nephropathy.•HLJDD possessed beneficial effects on diabetic nephropathy in db/db mice.•HLJDD ameliorated diabetic nephropathy via regulation of AGEs/RAGE/Akt/Nrf2 pathway and metabolic profiling.

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关键词

Diabetic nephropathy,Huang-Lian-Jie-Du Decoction,Network pharmacology,AGEs/RAGE/Akt/Nrf2 pathway,Metabolomics

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