Chemoproteomic profiling reveals celastrol as a potential modulator of cholesterol signaling

Yiyun Geng,Jingyuan Xu,Weichao Li,Qing Li, Chenjinxin Shen,Zhangshuang Deng,Yiqing Zhou

Chemical Communications（2022）

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摘要

We report a quantitative chemoproteomic approach that utilizes a clickable photoreactive probe for global profiling of celastrol targets, which may significantly improve the current understanding of celastrol's mode of action.

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