Increased Levels of Phospho-Tau217 in Neuron Cultures and CVN Mice Infected with Porphyromonas Gingivalis.

P. gingivalis infected neuronal cell cultures and chronically infected CVN mice display elevated p-tau217. In vitro this was apparent at low infection levels that might reflect the physiological level of gingipain exposure. Phospho-tau217 is emerging as a specific biomarker for AD and these results further validate P. gingivalis-infected neuron cultures and mice as models for AD.