Genome-wide association for protective variants in Alzheimer's disease in the Midwestern Amish.

Leighanne R Main,Yeunjoo E Song,Renee A Laux,Kristy L Miskimen,Michael L Cuccaro,Paula K Ogrocki,Alan J Lerner,Jeffery M Vance,M Denise Fuzzell,Sarada L Fuzzell,Jane L Sewell,Laura J Caywood,Michael B Prough,Larry D Adams,Jason E Clouse,Sharlene D Herington,William K Scott,Margaret A Pericak-Vance,Jonathan L Haines

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

We studied cognitively resilient individuals from a founder population to identify potential protective genetic variants for AD. We identified four SNPs associated with CN in at-risk adults over 75. These loci might influence cognitive resilience. Here we have shed some light on possible genetic factors that may contribute to protection from cognitive decline.

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