First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence
JOURNAL OF BIOMEDICAL OPTICS(2022)
摘要
Intraoperative FLIm could simultaneously detect the emission of PpIX and NAD(P)H from patients in vivo during craniotomy procedures. This approach doubles as a clinical tool to identify tumor areas while performing tissue resection and as a research tool to study tumor microenvironmental changes in vivo. Intraoperative FLIm of 5-ALA-induced PpIX and tissue autofluorescence makes a promising surgical adjunct to guide tumor resection surgery.
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关键词
5-ALA-induced PpIX fluorescence,brain tumor,fluorescence lifetime imaging,glioblastoma,nicotinamide adenine (phosphate) dinucleotide
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