Isoliquiritigenin alleviates diabetic symptoms via activating AMPK and inhibiting mTORC1 signaling in diet-induced diabetic mice

Lin Yang,Doudou Wang,Zhixin Zhang,Yu Jiang,Ying Liu

Phytomedicine（2022）

引用 5|浏览14

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摘要

•Isoliquiritigenin (ISL) treatment reduces blood glucose level and alleviates insulin resistance in high fat diet induced diabetic mice.•ISL treatment promotes hepatic glycogenesis and inhibits hepatic lipogenesis and fat accumulation.•ISL rapidly activates AMPK and inhibits mTORC1.•ISL reduces cellular ATP production.

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关键词

Isoliquiritigenin,Type 2 diabetes mellitus,AMPK,mTORC1,AKT,mitochondria

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