Chemical components analysis and in vivo metabolite profiling of Jian’er Xiaoshi oral liquid by UHPLC-Q-TOF-MS/MS

•The components and in vivo metabolism of JEXS were analyzed by LC-MS/MS.•142 compounds in JEXS were characterized, 54 of which were identified by standards.•52 prototypes and 126 metabolites of JEXS were characterized in bio-samples of rats.•The in vivo metabolic modes of chrysin-C-glycosyls were clarified for the first time.