Djhsp70s, especially Djhsp70c, play a key role in planarian regeneration and tissue homeostasis by regulating cell proliferation and apoptosis

•The cytoprotective effect on Djhsp70s, especially Djhsp70d, is conservative in planarians.•Djhsp70a and Djhsp70b, especially Djhsp70c are necessary for the planarian regeneration.•Djhsp70s are involved in homeostasis maintenance and regeneration process by regulating coordination of cell proliferation and apoptosis in planarians.