Chemoenzymatic One-Pot Reaction from Carboxylic Acid to Nitrile Via Oxime

Melissa Horvat,Victoria Weilch,Robert Radisch,Sebastian Hecko,Astrid Schiefer,Florian Rudroff,Birgit Wilding,Norbert Klempier, Miroslav Patek,Ludmila Martinkova,Margit Winkler

Catalysis science & technology（2022）

引用 13|浏览8

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摘要

We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.

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