ChemInform Abstract: Synthesis and Evaluation of the Substrate Activity of C-6 Substituted Purine Ribosides with E. coli Purine Nucleoside Phosphorylase: Palladium Mediated Cross-Coupling of Organozinc Halides with 6-Chloropurine Nucleosides.

Abdalla E. A. Hassan,Reham A. I. Abou-Elkhair,James M. Riordan,Paula W. Allan,William B. Parker,Rashmi Khare,William R. Waud,John A. Montgomery,John A. III Secrist

ChemInform（2012）

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摘要

Pd(IV)-Mediated cross-coupling reactions of ribofuranosylpurine (I) with organozinc halides (II) and subsequent deprotection afford the C-6 substituted purine ribosides (III) in satisfactory to high yields.

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