Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure via CMKLR1 in rats

Chemerin is an inflammatory adipocytokine through acting on G protein-coupled receptor, chemokine-like receptor (CMKLR)1. We previously demonstrated that long-term intraperitoneal administration with chemerin increased systolic blood pressure (BP) in mice. Since important nuclei regulating BP exist in the brain, we examined mechanisms of central BP control by chemerin-9.