IS Kpn40 -Mediated Mobilization of the Colistin Resistance Gene mcr-3.11 in Escherichia coli

Yu-Zhang He,Teng-Fei Long,Cai-Ping Chen, Bing He,Xing-Ping Li,Jessica Schuyler,Liang Chen,Xiao-Ping Liao,Ya-Hong Liu,Jian Sun

Antimicrobial Agents and Chemotherapy（2020）

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摘要

The mobile colistin resistance gene mcr-3 has globally disseminated since it was first reported in 2017 in Escherichia coli . In vitro mobilization assays in this study demonstrate the functionality of the composite transposon structure IS Kpn40-mcr-3.11-dgkA -IS Kpn40 in wild-type and recA − E. coli strains. These transpositions generated 4-bp duplications at the target sites.

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