Expression of LAG3 on tumor-infiltrating lymphocytes in salivary gland carcinomas

L Nachtsheim,C Arolt, M Meyer,V Ruesseler,N Wuerdemann, T Dreyer,S Gattenloehner,C Wittekindt,R Buettner,A Quaas,JP Klußmann

Abstract- und Posterband – 91. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Welche Qualität macht den UnterschiedLaryngo-Rhino-Otologie（2020）

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摘要

Introduction Salivary glad carcinomas (SGC) are rare head and neck malignancies. LAG3 belongs to the immune-checkpoint receptor proteins and can be found on the cell surface of cytotoxic and regulatory T cells. It controls T cell activation, response and growth. The expression of LAG3 and tumor infiltrate in SGC as well as the correlation to clinical and pathological characteristics was investigated. In addition, the prognostic significance of LAG3 expression in SGC was evaluated.

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Salivary Gland Tumors

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