Vulnerability of Social Defeats in the Overexpressed Striatal SHATI/NAT8L in Mice

[Background] The number of patients that have depressive disorder is increasing. However, the mechanism of depression onsets has not been completely revealed. In such situation, we are mention to SHATI/NAT8L. SHAT/NAT8L is a related protein as psychiatric disorder, and synthesize N-acetyl-aspartate (NAA). NAA is converted to N-acetyl-aspartyl-glutamate (NAAG), an agonist of mGluR3, by condensation with glutamate. We reported that SHATI/NAT8L-overexpressed mice in the striatum showed the prolonged immobility time in the forced swimming test and tail suspension test. Here, we revealed the involvement of SHATI/NAT8L in the vulnerability of social defeats stress by using depression model mice that was exposed to social defeat stress.