Involvement of Glycine Binding Site of NMDA Receptor in the Prefrontal Cortex of SHRSP/Ezo As an AD/HD Animal Model

Background: Attention deficit/ hyperactivity disorder (AD/HD) is a mild developmental disorder. We previously reported that stroke-prone spontaneously hypertensive rat/Ezo (SHRSP/Ezo) had high validity as an AD/HD animal model, because of its behavioral phenotype. It was reported that AD/HD had the front-cortical dysfunction, hypofrontality. Based on these reports, we hypothesized that SHRSP/Ezo as AD/HD animal model has some fronto-cortical incompetence. Thus, we evaluated the excitatory synaptic function in the PFC of SHRSP/Ezo using electrophysiological and pharmacological methods.