Specific Alterations of the Immune Checkpoint Secretome Are Linked with Antibacterial Immunity in Alcohol-Related Liver Disease

Antonio Riva,Douglas Corrigall,Huyen Adams,Nicola Harris,Yong Xin Sieh,Gavin Wright,Sarah Fairclough,Alex Evans,Debbie L. Shawcross,Marieta Simonova,Tanya Hadzhiolova,Slava Pavlova,Krum Katzarov,Roger Williams,Shilpa Chokshi

Journal of hepatology（2020）

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摘要

junction (TJ/AJ) genes including claudin 3, occludin, ZO-1, E/LIcadherin and catenins.Differential expression of TJ/AJ-modulating long non-coding RNAs was consistent with the observed transcriptional changes in coding genes.Interestingly, downregulated gene clusters did not achieve significant enrichment.Quantification of plasma D-Lactate and endotoxin (Lps) confirmed the presence of bacterial translocation in ARC vs HC.

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