Human Defensin-Inspired Discovery of Peptidomimetic Antibiotics
Proceedings of the National Academy of Sciences of the United States of America(2022)
摘要
SignificanceWe report the development of peptidomimetic antibiotics derived from a natural antimicrobial peptide, human α-defensin 5. By engaging multiple bacterial targets, the lead compound is efficacious in vitro and in vivo against bacteria with highly inducible antibiotic resistance, promising a useful therapeutic agent for the treatment of infections caused by antibiotic-resistant bacteria.
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关键词
defensins,peptidomimetic antibiotics,antimicrobial resistance,infections
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