Killer immunoglobulin-like receptor (KIR) genes are associated with the risk of episodes of high-level and detectable viremia among HIV controllers
F1000Research(2021)
摘要
Background: HIV controllers (HICs) constitute a heterogeneous group
of HIV-1 individuals able to suppress plasma viremia to low or
undetectable levels in the absence of antiretroviral therapy. Host
genetic factors may be involved in the sustained control of viral
replication observed. We investigated the distribution and the
potential impact of human leukocyte antigens (HLA)-B and -C alleles,
killer immunoglobulin-like receptor (KIR) genes, single nucleotide
polymorphisms (SNPs) of the NLRP3, CARD8 and IL-1β inflammasome
genes, and CCR5Δ32 mutation on the viral control among HICs.
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