Ultrahigh-speed, high-resolution, large-area optical coherence tomography (OCT) imaging for rapid evaluation of breast cancer surgical specimens (Conference Presentation)

The purpose of this study was to develop an ultrahigh-speed, high-resolution, large imaging area optical coherence tomography (OCT) imaging system for improved evaluation of breast cancer surgical specimens. A 2-axis direct-drive servo motorized linear translation stage enables automatic acquisition and stitching of multiple OCT volumes, providing large-area imaging of tissue sizes up to 10cm x 10cm surface area x 2mm imaging depth. OCT images of breast specimens with this system will demonstrate normal breast parenchyma, cysts, radial scars, benign neoplasms such as fibroadenoma, atypical ductal/lobular hyperplasia, and carcinomas in situ and invasive.