Cover Feature: Towards DNA‐Encoded Micellar Chemistry: DNA‐Micelle Association and Environment Sensitivity of Catalysis (Chem. Eur. J. 39/2021)

The development of DNA-compatible reactions is central to advance DNA-encoded library technology. Amphiphilic block copolymer micelles functionalized with sulfonic acid moieties assemble in water to micelles and localize the catalyst in them. DNA-aldehyde conjugates were reacted to target heterocycles by micelle-promoted Povarov- and Biginelli-reaction with minimal DNA damage. Strikingly, DNA-conjugates accumulated effectively in the micellar compartments as a prerequisite for compound synthesis. More information can be found in the Full Paper by R. Weberskirch, A. Brunschweiger, et al. (DOI: 10.1002/chem.202100980).