Синтез конъюгатов глицирризиновой кислоты с s-бензил-L-цистеином и их противовирусная активность

A new method for the synthesis of glycyrrhizic acid (GA) conjugates with S-benzyl-L-cysteine using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide is proposed. It is established that 3-O-{2-O-[N-(β-D-glucopyranosyluronoyl)-L-cysteine(S-benzyl)-N-(β-D-glucopyranosyluronoyl)-L-cysteine(S-benzyl)]}- (3β,20β)-11-oxo-olean-12-ene-30-(N-carbonyl-L-cysteine(S-benzyl)-3-yl is superior to GA in inhibiting the accumulation of HIV-1 virus-specific protein p24 (viral antigen) in MT-4 cell culture (IC 50 3 mg/mL, SI 90), and is 50 – 55 times less toxic to cells than azidothymidine.