Synthesis, Biological Evaluation and in Silico ADME Predictions of Some New Coumarin-Acetamide Derivatives As Potent Anti-Inflammatory Agents

A new series of 4-methyl-7-methoxycoumarin derivatives linked with three amide groups were prepared starting from 2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy) acetohydrazide, compound 4. TLC was used to ensure the purity of all new compounds, and IR, 1H NMR, and mass spectrometry, as well as elemental microanalyses, were used to confirm their structures. All of the target compounds were tested for anti-inflammatory activity. The results showed that most of the tested compounds exhibited significant anti-inflammatory activity in comparison to indomethacin (INM) as a reference drug. The results revealed that compound 8g was the most active one exceeding the activity of the reference INM. Moreover, compounds 8f and 8k showed approximately the same results as INM after 5 hr. In silico ADME prediction investigations also forecasting the drug-like characters of these compounds .