Progressive Development of Cefiderocol Resistance in Escherichia coli During Therapy Is Associated with Increased blaNDM-5 Copy Number and Gene Expression.

Patricia J Simner,Heba H Mostafa,Yehudit Bergman,Michael Ante,Tsigereda Tekle,Ayomikun Adebayo,Stephan Beisken,Kathryn Dzintars,Pranita D Tamma

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2021）

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摘要

Our patient's case suggests that increased copy numbers of bla NDM genes through translocation events is used by Enterobacterales to evade cefiderocol-mediated cell death. The frequency of increased NDM expression in contributing to cefiderocol resistance needs investigation.

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关键词

Escherichia coli,NDM,antimicrobial resistance,cefiderocol

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