Relaxin Attenuates Organ Fibrosis via an Angiotensin Type 2 Receptor Mechanism in Aged Hypertensive Female Rats.

Giannie Barsha,Sarah L Walton,Edmund Kwok,Katrina M Mirabito Colafella,Anita A Pinar,Lucinda M Hilliard Krause,Tracey A Gaspari,Robert E Widdop,Chrishan S Samuel,Kate M Denton

Kidney（2021）

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摘要

The antifibrotic and organ-protective effects of RLX, when administered to a severe model of hypertension, conferred cardiorenal protection in adult and reproductively senescent female rats to a great extent an ATR-mediated mechanism.

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关键词

aging,angiotensin type 2 receptor,basic science,cardiovascular system,females,fibrosis,hypertension,rats,relaxin

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