Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation

Woo Seong Ji,Hyun-Young Jang,Sang-Il Lee,Sang-Myeong Lee,Byung-Hyun Park

Journal of Immunology（2016）

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摘要

Conclusion Myeloid cell-specific deletion of SIRT1 appears to suppress CIA through modulation of DC maturation. Thus, careful investigation of DC-specific SIRT1 downregulation is needed to weigh the therapeutic utility of agents targeting SIRT1 in RA.

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