Dietary Sodium Restriction Changed Calcitonin, T3, T4, and Urinary Mineral Excretion in Healthy Women: 3370 Board # 239 June 2 9 30 AM - 11 00 AM

Medicine and Science in Sports and Exercise(2018)

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Abstract
PURPOSE: The purpose of this study was to examine the relationship between dietary sodium (Na) restriction and levels in hormone and urinary mineral excretion. METHODS: We used a part of the metabolic balance study (the duration: 21 days) data carried out in 2004. Subjects were 11 healthy women, aged 19-23 yrs. They were divided into two levels of dietary Na groups (G), i.e. Na restricted (R) G (n = 5) (NaCl: 6 g/d) and the Control G (n = 6) (NaCl: 12 g/d). Aldosterone (ALD), calcitonin (CT), parathyroid hormone, triiodothyronine (T3) and thyroxine (T4) were measured from the blood samples collected in the fasting morning. The second voided early morning urine (EMU) minerals {Na, potassium (K), calcium (Ca), magnesium (Mg), phosphorus (P) and zinc (Zn)} were also measured. RESULTS: ALD and CT levels were significantly higher in the Na RG than in the Control G (ALD: 16.5 ± 5.2 vs. 11.2 ± 3.4 ng/dL p<0.001, CT: 34.6 ± 14.1 vs. 21.7 ± 10.0 pg/mL, p<0.05). T3 and T4 levels were significantly lower in the Na RG than in the Control G (T3: 99.1 ± 22.8 vs. 111.1 ± 14.9 ng/dL p<0.05, T4: 6.2 ± 1.3 vs. 6.9 ± 1.1 μg/dL p<0.01). EMU-Na, Ca, Mg, P and Zn of the Na RG concentrations were significantly lower than those of the Control G (Na: 0.7 ± 0.4 vs. 1.5 ± 0.8 μmol/kg body weight (BW)/ min p<0.001, Ca: 19.3 ± 11.3 vs. 33.0 ± 16.6 nmol/kg BW/min p<0.001, Mg: 33.6 ± 10.2 vs. 38.9 ± 9.5 nmol/kg BW/min p<0.001, P: 165.0 ± 55.9 vs. 193.7 ± 57.4 nmol/kg BW/min p<0.05, Zn: 50.1 ± 12.4 vs. 64.1 ± 20.0 pmol/kg BW/min p<0.01), respectively. CONCLUSION: Our data showed that dietary Na restriction increased calcitonin and decreased both T3 and T4, and decreased minerals in the EMU. It was revealed that dietary Na restriction affects most of EMU-minerals as well as Na. This suggests that Na affected to the metabolism of the other minerals. Further studies are required to confirm the effects of Na restriction on the hormones.
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Key words
urinary mineral excretion,calcitonin,sodium
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