Inflammatory myofibroblastic tumor of the bladder

Objective To review the pathological and clinical features of inflammatory myofibroblastic tumor(IMT)of the bladder,and to discuss its diagnosis,treatment and prognosis.Methods The clinicaldata of 7 patients with IMT of the bladder were reviewed.There were 3 males and 4 females aged 10 to 54 years(mean 38).Lesions were 1.5 cm to 5.0 cm.The majority of the patients presented with hematuria.The masses of bladders were discovered by imaging studies and cystoscopys.Three cystoscopic biopsies and frozen section analysis of 2 specimens were performed,but no IMT was confirmed.Results All bladder IMTs were managed by partial cystectomy.By post-operative pathological examination,IMT of the bladder were diagnosed.By immunohistochemistry,lesions at least fotally expressed smooth muscle actin(7/7),AE1/AE3(7/7),vimentin(7/7).anaplastic lymphoma kinase(6/7),and most lacked S100(0/7),CD_(34)(017),CD_(117)(0/7).Follow-ups were available in 6 cases.There was no patient with recurrence during the follow up from 1 month to 60 months.Conclusions The IMT of the bladder is rare.The diagnosis mainly depends on pathological diagnosis.Partial cystectomy or transurethral resection could be the treatment choice. Key words: Urinary bladder neoplasms; Neoplasms,muscle tissue; Diagnosis; Therapy