Taxol Total Synthesis: Preparation of a Chiral Ring A Moiety via Biomimetic Cyclization and Evaluation of a Tandem Nitrile Oxide Strategy for Rings B/C.

Universitd Louis Pasteur, Laboratoire de Chimie Bio-Organique associd au CNRS, Facult6 de Pharmacie 74 route du Rhin BP 24, F-67401 Illkirch , CEA, CE-Saclay, Service des molecules marqudes Bat. 547, Ddpartement de Biologie Cellulaire et Moldculaire, F-92191 Gifisur-Yvette, and Departments of Molecular Genetics and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75235