A swift, facile and multicomponent synthesis of 4H-pyran-3-carbonitrile analogues via grinding process under solvent-free conditions

A novel 4 H -pyran-3-carbonitrile analogues have been synthesized conveniently using a highly efficient protocol via solvent-free, one-pot, multicomponent condensation of malononitrile, various aldehydes, and 5,5-dimethylcyclohexane-1,3‑dione along with TEA as catalyst under simple grinding approach. Simple handling, mild reaction conditions with superb alterations, inexpensive, environmental friendliness, avoiding toxic solvents, short reaction times (10 min), easy workup process, and higher product yields (89–96%) are remarkable benefits of this approach.