Abstract PO-251: Cervical screening in Latinas of 20-24 years old: findings from the Brazilian cervical cancer information system

Abstract Introduction: The Brazilian National Cancer Institute attests that cervical cancer screening should be performed once a year in women aged 25 to 64 years, then every three years after two consecutive negative exams. However, the first sexual activity in Latinas usually occurs in late adolescence, between 15 to 19 years old. Therefore, the aim of this study was to evaluate cervical cytopathological changes with suspected malignancy and/or high potential for progression to malignancy in Brazilian women of 20 to 24 years old. Methods: Cross-sectional, descriptive study which evaluated cervical smears with satisfactory sampling obtained in Brazil from 2006 to 2015 using data from the national database (SISCOLO – Brazilian Cervical Cancer Information System). Suspected malignancy or high potential for progression to malignancy was composed of: high-grade indeterminate squamous cell, high-grade indeterminate glandular cell, high-grade cell of indefinite origin, high-grade intraepithelial lesion, intraepithelial lesion with micro-invasion, invasive squamous cell carcinoma, adenocarcinoma in situ, invasive adenocarcinoma, and other neoplasms. Results: During this time period, 86 375 132 cervical screening tests with satisfactory sampling were performed in the country, with 862,875 (1%) having abnormal results suggestive of suspected malignancy or high potential for progression to malignancy. Of the tests with abnormal results, 704,886 (82%) were from the age group of 25 to 64 years and 69,035 (8%) were from the age group of 20 to 24 years. From 2006 to 2015, there was a decrease of 53% in the total number of cervical cancer screening tests performed in Brazil. Conclusion: In our study, a significant percentage of the abnormal test results were from Latinas of 20 to 24 years old. The precociousness of sexual initiation and the multiplicity of sexual partners can expose women to human papillomavirus at a very early age, which may explain the findings reported. Citation Format: Tulio L. Correa, Valquiria P. Garcez, Mariana S.T.C. Guelli, Carolina C. Cruz, Julia P. Lara, Matheus M.C. e Silva, Luana O. Rodrigues, Isabel C. Guglielmelli, Betina M Giordani. Cervical screening in Latinas of 20-24 years old: findings from the Brazilian cervical cancer information system [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-251.