Escherichia coli tRNA 2-selenouridine synthase SelU selects its prenyl substrate to accomplish its enzymatic function

Patrycja Szczupak,Ewa Radzikowska-Cieciura,Katarzyna Kulik,Rafał Madaj,Małgorzata Sierant,Agnieszka Krakowiak,Barbara Nawrot

Bioorganic Chemistry（2022）

引用 4|浏览11

暂无评分

摘要

•2-Selenouridine-tRNA synthase (SelU) is a two-faced enzyme that catalyzes S2U → Se2U.•SelU selects its specific prenyl substrate to produce geranylated S2U-tRNA.•Geranyl pyrophosphate (gePP) binds to SelU in the micromolar range.•The 7-aa fragment of the P-loop of SelU is a domain for recognition of gePP.•Methyl and various S-prenyl tRNAs serve as SelU substrates for selenation in vitro.

查看译文

关键词

Wobble nucleoside,Modified nucleoside,2-thiouridine,S2U,2-selenouridine,Se2U,tRNA 2‐selenouridine synthase,SelU,Geranyl,Prenyl

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要