Development of a dual antigen lateral flow immunoassay for detecting Yersinia pestis.

Derrick Hau, Brian Wade, Chris Lovejoy,Sujata G Pandit,Dana E Reed,Haley L DeMers,Heather R Green,Emily E Hannah,Megan E McLarty, Cameron J Creek, Chonnikarn Chokapirat,Jose Arias-Umana, Garett F Cecchini,Teerapat Nualnoi,Marcellene A Gates-Hollingsworth,Peter N Thorkildson,Kathryn J Pflughoeft,David P AuCoin

PLoS neglected tropical diseases（2022）

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摘要

LcrV is expressed by all virulent Y. pestis strains, but homologs produced by other Yersinia species can confound assay specificity. F1 is specific to Y. pestis but is not expressed by all virulent strains. Utilizing highly reactive mAbs, a dual-antigen detection (multiplexed) LFI was developed to capitalize on the diagnostic strengths of each target.

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