Emerging roles of DNA topoisomerases in the regulation of R-loops

Parasvi S. Patel,Rehna Krishnan,Razqallah Hakem

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2022）

引用 7|浏览16

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摘要

•Topoisomerases are crucial for maintaining R-loop homeostasis and genomic integrity.•Topoisomerases have important functions in regulating transcription and replication.•Inhibiting crucial functions of topoisomerases in maintaining genomic stability can be targeted for cancer therapy.

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关键词

DNA damage,Topoisomerases,DNA:RNA hybrids,DNA repair,Cell cycle

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