Adjuvant and neoadjuvant breast cancer treatments: A systematic review of their effects on mortality

•Clinical guidelines recommend > 20 adjuvant or neoadjuvant breast cancer options.•Randomised data on 1000–10,000 women are available for most options.•Breast cancer mortality or recurrence was reduced by 10–25% for most options.•Anthracycline chemotherapy and radiotherapy increased non-breast-cancer mortality.•Radiotherapy-related risks increased with increasing organ dose.