Impact of B.1.617 and RBD SARS-CoV-2 variants on vaccine efficacy: An in-silico approach

•The speedy evolution of new variants of SARS-CoV-2 is of high concern for Covid-19 Pandemic.•New B.1.617 variant (L452R & E484Q) caused a surge in the number of infections as well as re-infections in India.•In silico analysis showing RBD variants affecting the ability of CR3022 and ACE2 to bind with the SARS-CoV-2 RBD.•Docking results of RBD variants revealed lowest binding affinity of double mutant for antibody over other variants.•MD simulation of RBD variants showed that stability and flexibility of structure has been hampered.•The B.1.617 variant could lessen the impact of the current vaccine & causes chance of reinfections.