[Effects of the ITGA2B Nonsense Mutation (c.2659C > T, p.Q887X) on Platelet Function in a Mouse Model of Glanzmann's Thrombasthenia Generated with CRISPR/Cas9 Technology].

Fei Yang,Miao Jiang,Zeng-Hua Lin,Zhan-Li Xie,Zhen-Ni Ma,Li Yang,Hong Liu,Zhao-Yue Wang,Lu Zhou

Zhongguo shi yan xue ye xue za zhi（2022）

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摘要

A GT mouse model with ITGA2B c.2659 C>T (p.Q887X) nonsense mutation has been established successfully by CRISPR/Cas9 technology. The aggregation function of platelet in this model is defective, which is consistent with GT performance.

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关键词

CRISPR/Cas9 ,Glanzmann's thrombasthenia ,mouse model

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