Evaluation of plasma LC3B+extracellular vesicles as a potential novel diagnostic marker for hepatocellular carcinoma

Yong-Qiang Chen,Lu Zheng,Juan Zhou,Peng Wang,Lu Wang,Yue Zhang,Zhong-Song Man,Yan-Hong Chen,Feng Gu,Guo-Ping Niu

International Immunopharmacology（2022）

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摘要

•Tumor-released autophagosome was a new LC3B-positive extracellular vesicle (EV).•Plasma LC3B+ EVs profiles were identified as potential liver cancer biomarkers.•LC3B+ EVs carrying bioactive molecules are a cause of CD8+ T cell exhaustion.

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关键词

Liver cancer,Extracellular vesicles,Secretory autophagosome,Diagnostic marker,T cell exhaustion

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