Serum metabolomic research of the anti-pulmonary fibrosis effects of Shuangshen Pingfei Formula on bleomycin-induced pulmonary fibrosis rats

•An integrative approach based on GC-MS and UPLC-QE-MS metabolomics data as a comprehensive strategy to search potential pulmonary fibrosis (PF) biomarkers.•PCA and OPLS-DA were applied to find out the differences between the control (NS), model group (PF), and treat group (SSPF) to assess the influence of SSPF on the metabolic pattern.•The metabolic profile was investigated in the process of the occurrence and development of PF.•After SSPF treatment, the disorder of lipid, amino acid metabolism was regulated. Serine, proline, glutamine, dihydroxybenzoic acid, 4-guanidinobutyric acid, phosphatidylethanolamine, lecithin and 9,10-epoxyoctadecene acids may be useful as biomarkers of the anti-fibrosis effect of SSPF.