Association of Fasting Proinsulin Levels with Glycemic Profile in Indian Type 2 Diabetes Patients.

The results of the study demonstrated significant positive association between fasting proinsulin levels and glycemic indicators (p value FBS =0.001, HbA1c= 0.005, triglyceride =0.008). Proinsulin however has multiple associations with the diabetes pathophysiology which need to be studied further. Other studies have also demonstrated proinsulin to be an independent cardiovascular risk factor by stimulating plasminogen activator inhibitor-1 secretion and blocking fibrinolysis. Hence, proinsulin needs to be evaluated for use as a early marker for diabetes progression.