Eriodictyol mediated selective targeting of the TNFR1/FADD/TRADD axis in cancer cells induce apoptosis and inhibit tumor progression and metastasis

Shibjyoti Debnath, Abhisek Sarkar,Dipanwita Das Mukherjee, Subha Ray,Barun Mahata,Tarun Mahata,Pravat K. Parida,Troyee Das,Rupak Mukhopadhyay,Zhumur Ghosh,Kaushik Biswas

Translational Oncology（2022）

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摘要

•Eriodictyol induces Selective Cytotoxicity to tumor cells.•Eriodictyol enhances TNFR1 expression in cancer cells.•Eriodictyol targets TNFR1 to selectively mediate apoptosis and cytotoxicity to cancer cells.•Eriodictyol reduces tumour burden in experimentally induced lung metastasis in vivo.

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关键词

Flavonoids,CRISPR-Cas9,Cell death,Tumorigenesis,Selective cytotoxicity

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